Which Supplements Should You Take on Mounjaro? A UK Guide

Quick answer: Most people on Mounjaro (tirzepatide) or Wegovy (semaglutide) don't need a cupboard full of supplements. The priorities are getting enough protein, fibre and fluids from food, following the NHS advice on vitamin D, and considering a daily multivitamin if your appetite has dropped a lot. Always check with your prescriber or pharmacist before adding anything new.

Why nutrition matters more on a GLP-1

GLP-1 medicines slow down how quickly your stomach empties and reduce your appetite. That's how they help with weight loss, but eating smaller portions often means eating a narrower range of foods too. Over weeks and months, that can make it harder to get everything your body needs from diet alone.

The goal isn't to replace food with pills. It's to make every smaller meal count, and fill specific gaps where they're likely.

The nutrients worth watching

1. Protein

When you're eating less, protein is often the first thing to slip. It matters because protein contributes to the maintenance of muscle mass, and nobody wants to lose strength alongside weight. Try eating the protein part of each meal first, before you feel full. Our guide to getting enough protein on Mounjaro covers this in detail.

2. Vitamin D

The NHS already advises everyone in the UK to consider a 10 microgram (400 IU) vitamin D supplement daily in autumn and winter, and all year round if you don't get much sun. That doesn't change on a GLP-1. Vitamin D contributes to the maintenance of normal bones and to normal muscle function.

Our Vitamin D3 & K2 Dual Complex and D3 & K2 Gummies pair D3 with vitamin K2, which also contributes to the maintenance of normal bones. Note that 4,000 IU is a higher-strength dose; don't take more than one vitamin D product at once, and check with your GP if you're unsure what's right for you.

3. A broad-spectrum multivitamin

If your appetite has fallen significantly, a daily multivitamin is a simple safety net. For women, our Women's Multivitamin & Minerals includes iron, which contributes to the reduction of tiredness and fatigue, and vitamin B6, which contributes to the regulation of hormonal activity.

4. Magnesium

Magnesium is found in nuts, seeds, wholegrains and leafy greens, foods that can easily drop out of a smaller diet. Magnesium contributes to a reduction of tiredness and fatigue and to normal muscle function. If you choose to top up, Magnesium Glycinate 5 in 1 Gummies are an easy option.

5. Fibre and fluids

UK guidelines recommend 30g of fibre a day, and most adults already fall short. Eating less makes that gap wider. Build meals around vegetables, pulses, oats and wholegrains, and increase fibre gradually with plenty of water. If food alone isn't getting you there, Fibre Pro+ 3-In-1 Complex is one way to top up. Read more in our fibre on a GLP-1 guide.

What supplements can't do

Supplements aren't a treatment for medication side effects such as nausea, constipation or reflux. If you're experiencing side effects, speak to your prescriber or pharmacist. You can also report suspected side effects to the MHRA through the Yellow Card scheme.

A simple daily checklist

• Protein at every meal, eaten first
• Five portions of fruit and veg across the day, even if portions are small
• Around 6 to 8 glasses of fluid
• Vitamin D in line with NHS advice
• A multivitamin if your diet has become very limited

FAQs

Can I take supplements with Mounjaro?

Many people do, but always check with your prescriber or pharmacist first, especially if you take other medicines.

Do I need a multivitamin on Wegovy?

Not necessarily. If you're still eating a varied diet, food may cover your needs. A multivitamin makes more sense if your appetite and food variety have dropped a lot.

Should I take vitamin D on Mounjaro?

The NHS advice on vitamin D applies to everyone in the UK, whether or not you take a GLP-1.

Reviewed by John Lebach (Nutrition Coach) and Numan Caan (Senior Sports Scientist)

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This article is for general information only and isn't medical advice. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. If you take prescribed medication, are pregnant or breastfeeding, speak to your GP or pharmacist before starting a supplement.